Actin dynamics and cofilin-actin rods in alzheimer disease
نویسندگان
چکیده
منابع مشابه
Cofilin phosphatases and regulation of actin dynamics.
Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chr...
متن کاملActin, cofilin and cognition.
1. Nomura, M. & Li, E. Nature 393, 786–790 (1998). 2. Waldrip, W. R. et al. Cell 92, 797–808 (1998). 3. Sirard, C. et al. Genes Dev. 12, 107–119 (1998). 4. Winnier, G. M., Blessing, M., Labosky, P. A. & Hogan, B. L. M. Genes Dev. 9, 2105–2116 (1995). 5. Matzuk, M. M. et al. Nature 374, 354–356 (1995). 6. Conlon, F. L. et al. Development 120, 1919–1928 (1994). 7. Green, J. B., New, H. V. & Smith...
متن کاملThe ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury
ADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin cytoskeletal architecture and can reduce podocyte migration and motility. Recent studies suggest that cofilin-1 can be regulated through several extracellular...
متن کاملCofilin increases the torsional flexibility and dynamics of actin filaments.
We have measured the effects of cofilin on the conformation and dynamics of actin filaments labeled at Cys374 with erythrosin-iodoacetemide (ErIA), using time-resolved phosphorescence anisotropy (TPA). Cofilin quenches the phosphorescence intensity of actin-bound ErIA, indicating that binding changes the local environment of the probe. The cofilin concentration-dependence of the phosphorescence...
متن کاملIntroduction to Cofilin and its Regulation of Actin Dynamics
Article ID: WMC00631 Article Type: Review articles Submitted on:14-Sep-2010, 10:06:05 PM GMT Published on: 14-Sep-2010, 10:35:20 PM GMT Article URL: http://www.webmedcentral.com/article_view/631 Subject Categories:CELLULAR BIOLOGY
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cytoskeleton
سال: 2016
ISSN: 1949-3584
DOI: 10.1002/cm.21282